Titlebook: Gene- and Cell-Based Treatment Strategies for the Eye; Elizabeth P. Rakoczy Book 2015 Springer-Verlag Berlin Heidelberg 2015 Complex eye d

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https://doi.org/10.1007/1-4020-2586-6on the first two patients, one with dry AMD and one with Stargardt’s. Functional improvements were observed, but our conclusions were limited by the short follow-up time, lack of control group, and poor initial visual acuity. Importantly, no adverse events related to the treatment, such as hyperprol

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Monique M. Elseviers,Marc E. De Broeproach, utilizing surface-functionalized nanoparticles. Using this strategy, we are able to suppress choroidal neovascularization and fibrosis and restore visual acuity in several animal models including nonhuman primates. Our results show a promising alternative in our arsenal for anti-VEGF therapi

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Laura Weiss Roberts MD, MA,Mark Siegler MDhe development of recombinant technologies that led to the generation of recombinant viruses was it possible to treat genetically inherited diseases. Cell therapies are also a new way of treating disease and here we provide an overview of the development of the field.

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Book 2015al within the next 10–20 years. The treatments discussed relate to a wide variety of conditions, including macular degeneration, Leber’s congenital amaurosis, retinitis pigmentosa, choroideremia, and retinoschisis. The authors explain clearly how different gene and cell therapies work and provide fi

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Cellular mechanisms of nephrotoxicitylivery system. A detailed description of the construct, production, validation, and biological and pharmacological assessment follows. In addition, preclinical in vitro and in vivo data on mice, rats, and monkeys are presented. Finally, an early-stage clinical trial in human subjects is described.

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1612-3212 dge science into potential treatmentsIn this book, leading experts provide detailed descriptions of the exciting treatments that are expected to become part of the ophthalmologist’s arsenal within the next 10–20 years. The treatments discussed relate to a wide variety of conditions, including macula

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Elizabeth P. RakoczyExplains how emerging gene and stem cell therapies work.Covers treatments for a range of eye diseases.Describes the development of cutting-edge science into potential treatments