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Titlebook: Gene Transfer in the Cardiovascular System; Experimental Approac Keith L. March Book 1997 Springer Science+Business Media New York 1997 DNA

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發(fā)表于 2025-3-21 16:42:39 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Gene Transfer in the Cardiovascular System
副標(biāo)題Experimental Approac
編輯Keith L. March
視頻videohttp://file.papertrans.cn/382/381995/381995.mp4
叢書名稱Developments in Cardiovascular Medicine
圖書封面Titlebook: Gene Transfer in the Cardiovascular System; Experimental Approac Keith L. March Book 1997 Springer Science+Business Media New York 1997 DNA
描述The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their
出版日期Book 1997
關(guān)鍵詞DNA; cardiovascular; gene therapy; gene transfer; genes
版次1
doihttps://doi.org/10.1007/978-1-4615-6277-1
isbn_softcover978-1-4613-7881-5
isbn_ebook978-1-4615-6277-1Series ISSN 0166-9842
issn_series 0166-9842
copyrightSpringer Science+Business Media New York 1997
The information of publication is updating

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發(fā)表于 2025-3-21 23:29:14 | 只看該作者
Adenoviruses (Part II): Improvement of Adenoviral Vectors for Human Gene Therapy: E1 and E4 Deleted . Boulanger (Montpellier, France) for providing us with antibodies raised against the adenoviral fiber protein, Dr. T. Shenk (Princeton, New Jersey, U.S.A.) and Dr. P. Hearing (Stony Brook, New York, U.S.A.) for their kind gift of antibodies raised against the E4 gene products. We thank A. Gillardea
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發(fā)表于 2025-3-22 02:20:12 | 只看該作者
Adeno-Associated Virus and Other New DNA Virus VectorsThis feature may expand their utility in post-mitotic cells such as cardiac myocytes. Among DNA virus vectors, adenovirus (Ad) and adeno-associated virus type 2 (AAV) have been most thoroughly studied. The natural history of human AAV infection has not been studied as completely as Ad infection, but
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發(fā)表于 2025-3-22 07:59:16 | 只看該作者
Plasmid and Other Non-Viral Vectorsheim Biochemicals and Kurt Naujoks from Boehringer Mannheim Therapeutics for the critical reading of this manuscript and helpful discussions. In addition, I also thank the following individuals for providing me with information for this chapter: Uwe Michaelis from Boehringer Mannheim Therapeutics, M
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Catheter Based Local Drug and Gene Deliveryve growth in the number of procedures performed. Until just recently, however, there has been little advancement in reducing the frequency of restenosis and the incidence of angiographic restenosis, broadly defined as the partial or total reocclusion of the artery to 50% of the original lumen, has r
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Viral Vector-Based Vascular Gene Delivery: Basic Studies and Therapeutic Applicationsolved from initial studies demonstrating the feasibility of cell mediated and direct gene transfer into blood vessels to studies examining the pathophysiology of vascular diseases and therapeutic applications. Despite these advances, technical challenges persist related to optimization of vectors, e
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