Titlebook: Gene Therapy of Solid Cancers; Methods and Protocol Wolfgang Walther,Ulrike Stein Book 2015 Springer Science+Business Media New York 2015 c

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https://doi.org/10.1007/978-1-4020-5714-4ng tumor cell invasion and migration, angiogenesis, immunosuppression, as well as regulation of tumor stem cell properties. Hence, blocking the TGF-β signaling pathways may have a multifold therapeutic benefit for the treatment of solid tumors. Here, we describe the identification and selection proc

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https://doi.org/10.1007/978-3-642-45670-1entiation, proliferation, and survival, and is associated with angiogenesis and immune dysfunction during tumorigenesis. Double-stranded decoy oligodeoxynucleotide (ODN) targeting over-activated STAT3 in tumor cells have shown significant antitumor efficiency. Here, we describe the materials and met

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https://doi.org/10.1007/978-3-319-99837-4(herceptin) for breast cancer or Iressa (gefitinib) for non-small cell lung cancer among others are limited by lack of efficacy, cellular resistance, and toxicity. Dose escalation and combination therapies designed to overcome resistance and increase efficacy are limited by a narrow therapeutic inde

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C. A. Hendriks,K. Blok,W. C. Turkenburgy in more than 50 xenograft tumor models. The recombinant vaccinia virus strain has been equipped with heterologous expression cassettes for a luciferase-fluorescent protein fusion gene, bacterial beta-galactosidase, as well as a bacterial glucuronidase..The methods to investigate and monitor GLV-1h

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C. A. Timmermann,H. van den Belte Memorial Sloan-Kettering Cancer Center, pioneered bacterial therapy of cancer in the clinic with considerable success beginning in the late nineteenth century. After Coley died in 1936, bacterial therapy of cancer essentially ended. Currently there is much excitement in developing bacterial therap

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Wolfgang Walther,Ulrike SteinIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts

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978-1-4939-5592-3Springer Science+Business Media New York 2015

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Gene Therapy of Solid Cancers978-1-4939-2727-2Series ISSN 1064-3745 Series E-ISSN 1940-6029

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Aptamer Targeting the ERBB2 Receptor Tyrosine Kinase for Applications in Tumor Therapyis book chapter we describe the selection and characterization of DNA aptamers specific to the human epidermal growth factor receptor 2 (ERBB2/HER2), an oncogenic tyrosine kinase. First, a DNA aptamer library is applied and ERBB2-specific aptamers are selected using SELEX. Binders are subcloned into