Titlebook: Gene Therapy of Cancer; Peter Walden,Uwe Trefzer,Patricia Zambon Book 1998 The Editor(s) (if applicable) and The Author(s), under exclusiv

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Patterns of Chromosomal Imbalances in Carcinomas of the Respiratory Tract This is mainly due to the smoking habits worldwide. Whereas all major subtypes of lung cancer show a strong association with cigarette smoking alone carcinomas of the head and neck region are mainly caused by the cocarcinogenic effects of alcohol and nicotine intake.

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DRAFT

Telomerase Inhibition by Induced Expression of Antisense RNAal level is believed to trigger proliferative senescence [1,2]. In contrast, germ line cells and cancer cells do not show telomere shortening. The ribonucleoprotein telomerase, a RNA-dependent DNA polymerase, maintains telomere length in immortal cells and might be essential for unlimited growth of

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Use of the IGF-I Antisense Strategy in the Treatment of the Hepatocarcinomais a multi factorial disease linked to etiology factors as chemical carcinogens and virus. Chemotherapy and radiotherapy are relatively ineffective even after modern innovations. Surgery is the only treatment at the moment but it is not always applicable, it accounts for remission of 15–20% of the c

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Expression of Collagenase-3 (MMP-13) by Tumor Cells in Squamous Cell Carcinomas of the Head and Neckcomponents. At present, MMP gene family consists of 16 members, which, according to their substrate specificity and structure, are divided into subgroups of collagenases, gelatinases, stromelysins, and membrane type MMPs (MT-MMPs) (1). The expression of MMPs is upregulated in normal remodeling proce