Titlebook: Gene Therapy of Cancer; Methods and Protocol Wolfgang Walther,Ulrike Stein Book 20001st edition The Editor(s) (if applicable) and The Autho

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Immunizing Potential of Cytokine-Transduced Tumor Cellsermined by the type of cytokine, its quantity and activity, the histotype of the tumor and the molecules it releases, and its extracellular matrix (.). However, the relevant point is that a cascade of events other than tumor debulking are initiated by the transduced cytokines. Infiltration of differ

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Particle-Mediated Gene Transfer into Dendritic Cells consisting of antibody responses specific for conformational determinants, as well as, antigen-specific CD8.cytotoxic T cells and CD4.T-helper cells. For this reason, it represents an attractive novel approach for the clinical development of prophylactic and therapeutic vaccines against certain inf

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7 In Vitro Methods for Evaluation of ,-Based Anticancer Gene Therapyudies; 3) a large throughput of P450 genes and drugs can readily be tested to identify novel prodrug activation gene and prodrug combinations. This chapter describes growth inhibition and cytotoxicity assays that can be used to rapidly characterize the drug sensitivity of tumor cell lines transduced

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Combined Adenoviral Transfer of Tumor Suppressor and Cell-Cycle Genes for Tumor-Cell Apoptosis choice, which gene combination will be particularly efficient, depends on the pattern of mutated genes. We have recently reported that the cotransfer of . and . leads to a better induction of apoptosis and reduction of tumor growth than the transfer of either gene alone (.). In addition, it seems t

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Inhibition of Cell Growth by Antisense Oligonucleotides Targeting the Growth-Related Protein Kinase nduce apoptosis of cancer cells. Although these various approaches have not been validated clinically, these strategies are likely to identify compounds with less side effects compared to standard chemotherapeutic agents.

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Climate Science and Paleoclimatology, choice, which gene combination will be particularly efficient, depends on the pattern of mutated genes. We have recently reported that the cotransfer of . and . leads to a better induction of apoptosis and reduction of tumor growth than the transfer of either gene alone (.). In addition, it seems t