Titlebook: Gene Therapy for HIV and Chronic Infections; Ben Berkhout,Hildegund C.J. Ertl,Marc S. Weinberg Book 2015 American Society of Gene and Cell

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https://doi.org/10.1007/978-3-642-58274-5ion in human cells and play an active role in gene expression. Lastly, we explore therapeutic modalities based on expressed RNAs that are capable of countering infection, transcriptionally regulating the virus, and suppressing or activating the latent state.

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G. Bradley Bookatz M.D.,Spero G. Karas M.D.have the crucial advantage of not only protecting genetically modified cells from HIV-1 infection, but also neighboring cells, thus suppressing virus replication even if only a small fraction of cells is genetically modified. Accordingly, various cell types can be considered as potential in vivo pro

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Richard H. Bennett,Matthew H. Hulbertolecular interactions. SELEX technology enabled to isolate highly target specific aptamers from a random sequence oligonucleotide library. A number of aptamers for HIV-1 proteins as well as host proteins that interact with HIV-1 have been developed and some of them have potent viral neutralization a

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0065-2598 ular antiviral strategies (ribozymes, RNAi, RNAu, aptamers, This book centers ?on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Amp

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Gene Therapy Strategies to Block HIV-1 Replication by RNA Interference,rgeting host mRNAs that encode important viral cofactors, to the setup of appropriate preclinical test systems. Finally, we briefly discuss the relevance of this topic for other viral pathogens that cause a chronic infection in humans.