Titlebook: Gene Therapy for Cancer; Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swis Book 2007 Humana Press 2007 angiogenesis.apoptosis.cancer trea

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Gene Transfer for Chemoprotection and Enrichment of Hematopoietic Stem Cellsc gene products have been evaluated as tools for amplifying or enriching gene-modified HSCs in vivo. These include the homeobox transcription factors, selective amplifier genes, and drug resistance genes. The ability to enrich and repopulate the hematopoietic compartment with therapeutic gene-correc

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https://doi.org/10.1007/978-1-59745-222-9angiogenesis; apoptosis; cancer treatment; clinical trial; gene therapy; gene transfer; hematopoietic stem

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Nonviral Vector SystemsGene therapy requires efficient vectors for delivering therapeutic genes. Advances in developments of nonviral vectors have been established for improving the efficiency of gene delivery. This chapter describes different nonviral methods as well as their applications. Some new directions in developing nonviral vectors are also discussed.

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The Cooke triplet optimizations, at increasing the effectiveness of genetic vaccine formulations. Particular emphasis is placed on in vivo nonviral delivery technologies and modifications to safely achieve optimal antigen expression. We will also discuss implications for the future of genetic vaccines.

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https://doi.org/10.1007/978-1-4612-0681-1ly, the use of conditional replicating or oncolytic adenovectors in cancer gene therapy or virotherapy has received much attention. Clinical trials with E1-deleted adenovectors and oncolytic adenovirus have shown that adenovector-mediated cancer gene therapy is well tolerated and can produce clinica

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Rigid bodies and non-inertial frames, Many of these trials utilize Ad vectors as novel anticancer therapeutics. In recent years, however, initial enthusiasm and high expectations for successful clinical application of Ad-based vectors as efficient anticancer therapeutics has been dampened based on the data obtained during a series of c