Titlebook: Gene Regulation by Steroid Hormones III; Arun K. Roy,James H. Clark Conference proceedings 1987 Springer-Verlag New York Inc. 1987 Activat

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linear

Structure, Dynamics, and Cloning of the Estrogen Receptor,t the majority of functional estrogen receptor may reside in the nucleus, regardless of hormone status, and that binding of hormone to receptor leads to a tighter association of steroid-receptor complex with nuclear components. The nature of this association is not known, although a number of nuclea

過分

思考

Type II Binding Sites: Cellular Origin and an Endogenous Ligand,Markaverich and Clark, 1979; Watson and Clark, 1980) and malignanttissues. Type I sites represent the classical estrogen receptor, which has a high affinity for estradiol (.. = 0.1 ? 1.0 n.) and is present in target tissues in relatively low quantities. Nuclear type II sites appear to be a specific

獎牌

Human Progesterone Receptors Have Two Intracellular Hormone Binding Proteins That Are Covalently Morganization nor the nuclear sites of action of these proteins is resolved. The questions that persist include the size and number of hormone-binding subunits of the holoreceptors and the means by which receptors are transformed* to tight chromatin-binding proteins in response to hormone treatment. W

無可爭辯

The Two Phosphorylation Reactions of the Progesterone Receptor,mone interacts with a specific receptor. The second step is the tight binding of the steroid-receptor complex to chromatin, where it modulates the transcription of specific genes. We have recently observed, in the case of the progesterone receptor, the existence of a third step involving a hormone-d

無可爭辯

Receptor-Mediated Action of the Vitamin D Hormone, Fig. 1, 1,25(OH).D. is formed in the kidney according to the calcium and phosphorus needs of the organism (Haussler and McCain, 1977). Its main functions are the stimulation of intestinal calcium and phosphate absorption as well as bone remodeling. In addition to its mineral conservation effects in

額外的事

Characterization of the Nuclear Binding Sites (Acceptor Sites) for a Steroid Receptor,n of gene transcription (Thrall et al., 1978; Spelsberg et al., 1983). Although steroids can affect the rate of processing and stability of mRNAs (Moore et al., 1984) as well as membrane transport, one of the major sites of action appears to be directed at the transcription of the genes. For steroid

拋射物

Antibodies to Estrogen, Progesterone, Glucocorticoid, Vitamin D Receptors and Autoantibodies to Andeans, 1974; Liao, 1975; Muldoon, 1980; Schrader, et al., 1981; Schmidt and Litwack, 1982; Jensen et al., 1982; Ringold, 1985). Specific receptors for a number of steroid hormones have been purified (O’Malley and Schrader, 1976; Govindan, 1979; Kuhn et al., 1975; Pike et al., 1982; Jensen et al., 198

Innocence