Titlebook: Gastrointestinal Motility; Proceedings of the 9 Claude Roman (Dr. Sc., Professor of Physiology) Conference proceedings 1984 MTP Press Limit

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-Pro,, ,-Trp, Substance P: an Effective Antagonist of Exogenous and Endogenous Substance Pcontracts in the presence of substance P via direct and indirect mechanisms (3). The role of substance P as a neurotransmitter remains incompletely understood (4,5). The recent development of substance P antagonists (6) may provide a method to define the physiologic effects of substance P. We invest

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Variability of Pressure and Myoelectrical Activity Recorded from the Lower Esophageal Sphincter of Ffined to studies in anesthetized animals. Our aim in this study was to record LES pressure and electrical activity concurrently from conscious opossums. In four animals, we performed a cervical esophagostomy and implanted bipolar electrodes on the abdominal esophagus, LES, gastric antrum and duodenu

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Regulation of Gastric Antral Slow Wave Frequency by Prostaglandinsing electrical and mechanical behavior is not fully understood. In antral circular muscle, PGs decrease the force of contractions by decreasing maximum depolarization of the slow wave (7). Preliminary observations have suggested that endogenous PGs also regulate slow wave frequency (7). Experiments

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Stimulating Effects of Cisapride on Antroduodenal Motility in the Conscious Dog or gastric cannulas. In the digestive state, cisapride (1.25 mg/kg p.o.) doubled contractile amplitude, reduced (20 %) contractile frequencies of antrum and duodenum, and improved antroduodenal coordination (25 → 60 %). The minimal effective dose was 0.31 mg/kg p.o. Cisapride was significantly more