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Titlebook: Gastric Inhibitory Polypeptide; John Canvin Brown Book 1982 Springer-Verlag Berlin, Heidelberg 1982 Gastric inhibitory polypeptide.biosynt

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發(fā)表于 2025-3-21 18:37:53 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Gastric Inhibitory Polypeptide
編輯John Canvin Brown
視頻videohttp://file.papertrans.cn/381/380828/380828.mp4
叢書名稱Monographs on Endocrinology
圖書封面Titlebook: Gastric Inhibitory Polypeptide;  John Canvin Brown Book 1982 Springer-Verlag Berlin, Heidelberg 1982 Gastric inhibitory polypeptide.biosynt
描述Dr. Raymond Pederson, Dr. Jill Dryburgh and I commenced work on GIP in 1968, when, with the generous help of Professor Viktor Mutt and Professor Erik Jorpes of the Karolinska Inst,itute, Stockholm, we were able to establish that there existed an inhibitory material for acid secretion in cholecystokinin-pancreozymin prepara- tions. Once the physiological evidence for the inhibitor was established it seemed appropriate to seek help in its isolation. Dr. J. Dryburgh and Dr. R. Pederson were left to bioassay fractions in Vancouver whilst I enjoyed the company of Professor Mutt at the Karolinska for one year, as a Medical Research Council of Canada Visiting Scientist. Purification of the inhibitory factor proceeded rapidly due, in no small measure, to Professor Mutt‘s untirmg efforts on my behalf. Later that year, Dr. Dryburgh joined us in Stockholm to begin the sequence work on GIP. This was completed late in 1970 in Vancouver. In Stockholm in June 1970, I met a fellow Canadian Dr. John Dupre (McGill University) at a cocktail party who kept commenting about the possibility of GIP being an insulinotropic hormone, the "incretin" of earlier days. At that time, gastrointestinal physiologis
出版日期Book 1982
關(guān)鍵詞Gastric inhibitory polypeptide; biosynthesis; cholecystokinin; diabetes; diabetes mellitus; glucagon; horm
版次1
doihttps://doi.org/10.1007/978-3-642-81771-7
isbn_softcover978-3-642-81773-1
isbn_ebook978-3-642-81771-7Series ISSN 0077-1015
issn_series 0077-1015
copyrightSpringer-Verlag Berlin, Heidelberg 1982
The information of publication is updating

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沙發(fā)
發(fā)表于 2025-3-21 22:22:47 | 只看該作者
Assemblages of Drugs, Spaces and Bodies,ency of their inhibitory actions on gastric physiology, in innervated and denervated preparations, observed. The second approach has been via attempts to isolate and purify the substances from the gastro-intestinal mucosa which produce the inhibitory effects.
板凳
發(fā)表于 2025-3-22 00:41:45 | 只看該作者
Lisa M. Hoffman,Hope Reidun St. Johnroinsular axis was active or even hyperactive in maturity-onset diabetes. This later suggested to several groups a possible involvement of GIP, which has been considered to be a major component of the axis, in diabetic situations.
地板
發(fā)表于 2025-3-22 05:11:15 | 只看該作者
Assembling and Supplying the ISSPederson 1970). The search for the inhibitor in preparations containing CCK-PZ was prompted by the physiological studies of Brown and Pederson (1970), in which evidence was presented that CCK-PZ itself could not be the inhibitor of gastric acid secretion in the dog.
5#
發(fā)表于 2025-3-22 12:47:16 | 只看該作者
Assembling Health Care Organizationsdered to belong to that series of cells referred to by Pearse (1969) as the APUD cells or endocrine polypeptide cells. The GIP cell was tentatively considered, as a result of electron microscopy, to be the D. cell because the distribution most closely matched the small granule-containing cell first described by Vassallo et al. (1971).
6#
發(fā)表于 2025-3-22 16:26:36 | 只看該作者
Localization,dered to belong to that series of cells referred to by Pearse (1969) as the APUD cells or endocrine polypeptide cells. The GIP cell was tentatively considered, as a result of electron microscopy, to be the D. cell because the distribution most closely matched the small granule-containing cell first described by Vassallo et al. (1971).
7#
發(fā)表于 2025-3-22 17:08:25 | 只看該作者
8#
發(fā)表于 2025-3-22 21:27:33 | 只看該作者
Pathophysiology,roinsular axis was active or even hyperactive in maturity-onset diabetes. This later suggested to several groups a possible involvement of GIP, which has been considered to be a major component of the axis, in diabetic situations.
9#
發(fā)表于 2025-3-23 04:58:27 | 只看該作者
Summary and Conclusions,Pederson 1970). The search for the inhibitor in preparations containing CCK-PZ was prompted by the physiological studies of Brown and Pederson (1970), in which evidence was presented that CCK-PZ itself could not be the inhibitor of gastric acid secretion in the dog.
10#
發(fā)表于 2025-3-23 07:15:57 | 只看該作者
Book 1982Jorpes of the Karolinska Inst,itute, Stockholm, we were able to establish that there existed an inhibitory material for acid secretion in cholecystokinin-pancreozymin prepara- tions. Once the physiological evidence for the inhibitor was established it seemed appropriate to seek help in its isolation
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