| 書目名稱 | Gamma-Glutamyl Transpeptidases |
| 副標(biāo)題 | Structure and Functi |
| 編輯 | Immacolata Castellano,Antonello Merlino |
| 視頻video | http://file.papertrans.cn/381/380608/380608.mp4 |
| 概述 | Comprehensive, up-to-date overview.Includes supplementary material: |
| 叢書名稱 | SpringerBriefs in Biochemistry and Molecular Biology |
| 圖書封面 |  |
| 描述 | ?Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson’s disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers?current knowledge about the structure-function relationship of γ-GTs and?gives information about?applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.? |
| 出版日期 | Book 2013 |
| 關(guān)鍵詞 | Cellular redox homeostasis; Enzymes; Glutathione metabolism; Inflammation; Oxidative stress; Transferases |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-0348-0682-4 |
| isbn_softcover | 978-3-0348-0681-7 |
| isbn_ebook | 978-3-0348-0682-4Series ISSN 2211-9353 Series E-ISSN 2211-9361 |
| issn_series | 2211-9353 |
| copyright | The Author(s) 2013 |
|Archiver|手機版|小黑屋|
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