Titlebook: GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity; Denis J. Dupré,Terence E. Hébert,Ralf Jockers Book 2012 Spri

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Denis J. Dupré,Terence E. Hébert,Ralf JockersThis is the first book addressing specifically the assembly of G protein coupled receptors signaling complexes.Several colors images.Compilations of manuscripts made from experts in the field

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GPCR Oligomerization: Contribution to Receptor Biogenesis,hat trafficking from the endoplasmic reticulum to the plasma membrane is strictly regulated and involves interactions with specific proteins, such as resident ER chaperones. These interactions help with GPCR folding, but more importantly, they ensure that only properly folded proteins proceed from t

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,The Functional Size of GPCRs – Monomers, Dimers or Tetramers?,r of studies have since weighed in on this notion. Are native, functional GPCRs monomers, dimers or as some would suggest even higher order structures? Here, we review some of the latest evidence regarding the organization of these receptors in both homo- and hetero-oligomeric formats, with a partic

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Regulated GPCR Trafficking to the Plasma Membrane: General Issues and the CCR5 Chemokine Receptor Ell biology and pharmacology. This phenomenon requires a complex network of interactions between GPCRs with either chaperones and escort proteins or gatekeepers, which are respectively involved in the progression of GPCRs along the biosynthetic pathway to the plasma membrane or in their retention in

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,Synthesis and Assembly of G Protein βγ Dimers: Comparison of , and , Studies,(GPCRs) in the human genome to transduce extracellular signals across the plasma membrane. The synthesis of the constituent G protein subunits, and their assembly into Gβγ dimers and G protein heterotrimers, determines the signaling repertoire for G-protein/GPCR signaling in cells. These synthesis/a