Titlebook: GABA: Receptors, Transporters and Metabolism; Chikako Tanaka (Professor Emeritus, Director),Norm Book 1996 Birkh?user Verlag 1996 Calcium.

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GABA Transporters: Structure, Function and Mechanismin the termination of synaptic transmission. The GABA transporter GAT-1 is the first neurotransmitter transporter to be purified, reconstituted and cloned. It belongs to a large superfamily of neurotransmitter transporters. Its properties and its relation to the other family members will be discusse

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Heterogeneity of Brain GABA Transporterserapeutic targets, we have applied a combined approach including cDNA cloning, pharmacological characterization, mRNA localization, and synthesis of novel GABA uptake inhibitors. Four high-affinity GABA transporters are present in brain and each has a unique pattern of mRNA distribution, with multip

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Developmental Expression of the GABA Transporter GAT4otransport with sodium utilizing the energy stored in transmembrane electrochemical gradients generated by primary ion pumps. Studies on neurotransmitter uptake indicated the existence of multiple uptake systems, each relatively selective for a specific neurotransmitter. A family of Na./Cl. neurotra

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GABAB Receptor Control of Transmitter Release in the Spinal Cordected dorsal horn slice, evoked by electrical stimulation of primary dorsal afferents. CGP36742, CGP55845A and CGP52432 reversed the inhibitory effect that (?)-baclofen had on the stimulated outflow of GABA, glutamate and substance P-like immunoreactivity. CGP56999A was without effect on the baclofe

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Role of GABAA and GABAB Receptors in Ca++ Homeostasis and Transmitter Release in Cerebellar Granule s well as GABA. receptors. These receptors are coupled to regulation of transmitter release as well as intracellular Ca. homeostasis. Transmitter release elicited by moderate depolarization can be inhibited either by GABA. or GABA. receptor agonists whereas transmitter release evoked by a more prono

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Interactions between Endogenous L-DOPA and GABA, Systems for Cardiovascular Control in the Rat Nucle by bicuculline 10 ng. By microdialysis, basal L-DOPA release was reduced by muscimol 10 to 30 μM perfused via a probe by 50–60% whereas increased by bicuculline 30 μM by 40%. Pressor responses to 300 ng GABA were reduced by 50% by a competitive L-DOPA antagonist, L-DOPA methyl ester 1 μg. Meanwhile

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The Molecular Biology of GABAA Receptors and Its Applications, α2 and α3 subunits discovered were much more similar to each other than to a β subunit and hence these were designated as in two families, α and β (2). The range has been extended in studies, mainly by Peter Seeburg and co-workers and in some cases by others (reviewed in refs. 3,4) to a present to

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Modelling Functional Domains of the GABAA Receptor Chloride Channeluctural motif that may be coupled to channel gating. We recently identified amino acids (F65 and H102 in bovine . 1 subunit) as sites of photoaffinity labelling with GABA and benzodiazepine (BZ) ligands respectively. The two domains, TIDVFFR(61–67) for GABA and TPDTFFH(96–102) for BZ show sequence h