Titlebook: G Protein-Coupled Receptors in Drug Discovery; Wayne R. Leifert Book 2009 Humana Press 2009 Calcium.Cellular signalling.Chemokine.Drug dev

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Margret Liehn,Hannelore Schlautmanncular targets was elucidated. Over the years, this family of proteins has become more important in the understanding and treatment of different human pathologies, representing today close to 30% of the molecular targets of all marketed drugs. The sequencing of the human genome unveiled the existence

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Margret Liehn,Hannelore Schlautmannon (FDA)-approved drugs. Consequently, there are a wide variety of . plate-based screening technologies that enable the measurement of compound affinity, potency, and efficacy for almost every type of GPCR. However, to maximize success it is prudent to ensure that (i) the most suitable assay formats

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,Versuche über Lochleibungsdruck,ial role in drug discovery today. Classically, a number of drugs based on GPCRs have been developed for such different indications as cardiovascular, metabolic, neurodegenerative, psychiatric, and oncologic diseases. Owing to the restricted structural information on GPCRs, only limited exploration o

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Conference proceedings 1986Latest edition discovery. Yet, little is known about the specific interactions between GPCRs and G proteins. For a better perspective on the ternary complex dynamics, we adapted a β.-adrenergic receptor(β.AR)–tetGs. reconstitution system and found evidence that for efficient coupling of the β.AR to Gs does not re

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,Jernej Lorenci: “People Are the Key”,ew results and decisions based on them. The simple data summaries are the basis for all composite assay and screening data quality measures, for example, the signal-to-noise ratio, signal-to-background ratio, assay and screening window coefficients . and ., or strictly standardized mean difference (

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