| 書(shū)目名稱(chēng) | G Protein-Coupled Receptors - Modeling and Simulation | | 編輯 | Marta Filizola | | 視頻video | http://file.papertrans.cn/381/380012/380012.mp4 | | 概述 | This book is unique in its sort.The GPCR field is fast evolving, and computational techniques such as those described in this book, are becoming more and more utilized.Includes state-of-the-art views | | 叢書(shū)名稱(chēng) | Advances in Experimental Medicine and Biology | | 圖書(shū)封面 |  | | 描述 | G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of these receptors since 2007, and this information, integrated with dynamic inferences from computational and experimental methods, holds great potential for the discovery of new, improved drugs. This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the | | 出版日期 | Book 2014 | | 關(guān)鍵詞 | Bioinformatics; Computational Methods; G Protein-Coupled Receptors; GPCR Dynamics; GPCR Structure; Protei | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-007-7423-0 | | isbn_softcover | 978-94-024-0258-2 | | isbn_ebook | 978-94-007-7423-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 | | issn_series | 0065-2598 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 201 |
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