Titlebook: G Protein Signaling Mechanisms in the Retina; Kirill A. Martemyanov,Alapakkam P. Sampath Book 2014 Springer Science+Business Media New Yor

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Modulation of TRPM1 and the mGluR6 Cascade in ON Bipolar Cellse photoreceptor–ON bipolar cell synapse must also be adaptive, enhancing rapid changes in illumination while attenuating slower, more long-lasting changes in order to avoid saturation of downstream synapses. Calcium appears to play a major role in this form of short-term plasticity. Finally, recent

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The Role of Dopamine in Fine-Tuning Cone- and Rod-Driven Visionarried by the GABA. receptor channel. This sensitizing GABAergic input is crucial for increasing the light response amplitudes and extending the operational range of rod bipolar cells. These recent findings expanded the role of dopamine in retinal processing from its well-established function of sup

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Regulation of Electrical Synaptic Plasticity in the Retina by G-Protein-Coupled Receptorsar cues. The molecular mechanisms that transduce these signals are varied and specific to each cell type. Dopamine D1, and in some cases D2-like receptors, control coupling in horizontal cell, amacrine cell, and ganglion cell networks. In the AII amacrine cell, a balance between activity-dependent s

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Formen der Zusatz- und Sozialleistungen,ceptors (GPCRs). Our understanding of the key steps of signal transfer from GPCRs to G proteins and further downstream to G protein effectors has been greatly advanced through extensive biochemical studies in rod photoreceptors. This review focuses on the coupling of the visual G protein transducin

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