| 書目名稱 | Free-Radical-Induced DNA Damage and Its Repair | | 副標(biāo)題 | A Chemical Perspecti | | 編輯 | Clemens Sonntag | | 視頻video | http://file.papertrans.cn/349/348001/348001.mp4 | | 概述 | Provides an invaluable reference tool for the study of free radical-induced DNA damage and its repair, balancing the chemical and molecular approaches | | 圖書封面 |  | | 描述 | The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, | | 出版日期 | Book 2006 | | 關(guān)鍵詞 | DNA; DNA Reparatur; DNA Sch?den; DNA damage; DNA repair; Hydra; Mechanismen; Radikalchemie; mechanisms; radic | | 版次 | 1 | | doi | https://doi.org/10.1007/3-540-30592-0 | | isbn_softcover | 978-3-642-06554-5 | | isbn_ebook | 978-3-540-30592-7 | | copyright | Springer-Verlag Berlin Heidelberg 2006 |
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