| 書目名稱 | Fc Receptors | | 編輯 | Marc Daeron,Falk Nimmerjahn | | 視頻video | http://file.papertrans.cn/342/341529/341529.mp4 | | 概述 | Written by leading experts in the field.Provides a comprehensive and up to date overview of Fc receptors.Covers aspects of Fc receptor-targeted therapies for the treatment of inflammation, cancer and | | 叢書名稱 | Current Topics in Microbiology and Immunology | | 圖書封面 |  | | 描述 | .This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, .Old and New FcRs., deals with the long-sought-after FcμR and the recently discovered FCRL family and TRIM21. Part II, .FcR Signaling., presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, .FcR Biology., addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, .FcRs and Disease., discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, .FcRs and Therapeutic Antibodies., the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes. | | 出版日期 | Book 2014 | | 關(guān)鍵詞 | Agonist antibodies; Calcium channels; Fc receptors; FcR; FcR signaling; Glycosylation; Humanized mice; Lipi | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-07911-0 | | isbn_softcover | 978-3-319-37909-8 | | isbn_ebook | 978-3-319-07911-0Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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