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Titlebook: Exscalate4CoV; High-Performance Com Silvano Coletti,Gabriella Bernardi Book 2023 The Editor(s) (if applicable) and The Author(s), under exc

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發(fā)表于 2025-3-21 18:33:15 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Exscalate4CoV
副標(biāo)題High-Performance Com
編輯Silvano Coletti,Gabriella Bernardi
視頻videohttp://file.papertrans.cn/320/319784/319784.mp4
概述Offers a comprehensive view of one of most important efforts in the research of drugs against the SARS-CoV-2 virus.Shows the different efforts from a multidisciplinary point of view.Provides an‘in-dep
叢書(shū)名稱SpringerBriefs in Applied Sciences and Technology
圖書(shū)封面Titlebook: Exscalate4CoV; High-Performance Com Silvano Coletti,Gabriella Bernardi Book 2023 The Editor(s) (if applicable) and The Author(s), under exc
描述.This book highlights the different aspects of the research project “E4C Horizon 2020 European Project” aimed at fighting the coronavirus by combining the best supercomputing resources and artificial intelligence with state-of-the-art experimental facilities up through clinical validation...Coronavirus disease has become an important public issue across the globe since December 2019. There is an urgent need to develop potent anti-COVID-19 agents for the prevention of the outbreak and stop viral infections...To this aim, a public–private consortium composed by European and national infrastructures, center of excellence, universities, and a pharmaceutical company started the E4C Horizon 2020 European..Project: Its core idea was to use the EXaSCale smArt pLatform Against paThogEns (EXSCALATE) supercomputing platform for a process known as “drug repurposing”, namely to identify the most promising safe in man drugs for immediate treatment of the already infected population and then novel pan-coronavirus inhibitors to address future emergencies...This ambitious goal exploited a “chemical library” of 500 billion molecules, thanks to a processing capacity of more than 3 million molecules p
出版日期Book 2023
關(guān)鍵詞Exascale Computing; drug discovery; drug research against the Sars-Cov2; LIGATE project; SARS-CoV-2; mole
版次1
doihttps://doi.org/10.1007/978-3-031-30691-4
isbn_softcover978-3-031-30690-7
isbn_ebook978-3-031-30691-4Series ISSN 2191-530X Series E-ISSN 2191-5318
issn_series 2191-530X
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl
The information of publication is updating

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發(fā)表于 2025-3-21 20:57:29 | 只看該作者
The Drug Repurposing Strategy in the Exscalate4CoV Project: Raloxifene Clinical Trials,Cale smArt pLatform Against paThogEns for CoronaVirus (EXSCALATE4CoV; E4C), was used to identify drug candidates for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. E4C identified raloxifene as having great therapeutic potential, confirmed by in vitro data, which led to the p
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發(fā)表于 2025-3-22 04:11:38 | 只看該作者
The High-Performance Computing Resources for the EXSCALATE4CoV Project,n the case of a public health emergency, such as the ongoing coronavirus disease 2019 (COVID-19) pandemic, this identification needs to be accomplished quickly to support the rapid initiation of effective treatments to minimize casualties. The utilization of supercomputers, or more generally High-Pe
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發(fā)表于 2025-3-22 13:34:26 | 只看該作者
The Role of Structural Biology Task Force: Validation of the Binding Mode of Repurposed Drugs Againion, is a validated drug target for treating COVID-19. The structure of Mpro has been elucidated by macromolecular crystallography, but owing to its conformational flexibility, finding effective inhibitory ligands was challenging. Screening libraries of ligands as part of EXaSCale smArt pLatform Aga
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發(fā)表于 2025-3-22 23:02:42 | 只看該作者
Exploiting Drug-Discovery Research for Educational Purposes,ience in society has become a role of science for society, underscoring the importance of effective communication in fostering scientific literacy. Informal science education experiences, facilitated by the more widespread implementation of information technologies, are becoming increasingly relevan
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發(fā)表于 2025-3-23 02:14:02 | 只看該作者
Beyond the Exscalate4CoV Project: LIGATE and REMEDI4ALL Projects,rimary health and societal priority. At the same time, we became conscious that technological resources are often not used in the most efficient manner. The LIGATE and REpurposing MEDIcines For All (REMEDI4ALL) projects started on the large-scale mobilization efforts of the EXaSCale smArt pLatform A
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發(fā)表于 2025-3-23 06:58:56 | 只看該作者
https://doi.org/10.1007/978-3-031-30691-4Exascale Computing; drug discovery; drug research against the Sars-Cov2; LIGATE project; SARS-CoV-2; mole
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