Titlebook: Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy; Divya Vohora Book 2021 Springer Science+Bu

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Experimental and Translational Methods to Screen Drugs Effective Against Seizures and Epilepsy978-1-0716-1254-5Series ISSN 0893-2336 Series E-ISSN 1940-6045

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Andreas Kornelakis,Horen VoskeritsianSince the discovery of phenytoin in the 1930s, almost all antiseizure drugs (ASDs) have been identified by their effects in animal models, and millions of patients have profited from the successful translation of animal data into the clinic. However, several unmet clinical needs remain, including re

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Zoltan J. Acs,László Szerb,Erkko Autiod 30% of patients become resistant. Better understanding of epileptogenesis, the process in which the injury-induced cellular and subcellular modifications transform a healthy neuronal network to a malfunctioned state, has the potential to generate novel, more effective treatments. Creating a model

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Zoltan J. Acs,László Szerb,Erkko Autioal pathophysiological pattern. These models are being used for the screening of new antiseizure drugs as well as for the evaluation of associated cell-signaling events. Considering these applications, in this chapter, we describe a novel method for the screening of antiseizure molecules using an in

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Methodology and Data Description,ventional MES test, seizures are induced by applying an electrical stimulus of high intensity and high frequency for a short duration, which evokes tonic seizures that are manifested by a rigid extension of the hindlimbs. The subcutaneous (s.c.) PTZ test is in turn employed to produce clonic seizure

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Global Environmental Changes in South Asiastanding the process of epileptogenesis, determining the natural history of the disease, and discovering new therapies. Central to these questions is seeing the seizures behaviorally and physiologically. Because the seizures occur spontaneously and unpredictably, continuous EEG and video monitoring