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Titlebook: Experimental Models of Parkinson’s Disease; Yuzuru Imai Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license

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發(fā)表于 2025-3-21 18:21:30 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱(chēng)Experimental Models of Parkinson’s Disease
編輯Yuzuru Imai
視頻videohttp://file.papertrans.cn/319/318884/318884.mp4
概述Includes cutting-edge techniques.Provides step-by-step detail essential for reproducible results.Contains key implementation advice from the experts
叢書(shū)名稱(chēng)Methods in Molecular Biology
圖書(shū)封面Titlebook: Experimental Models of Parkinson’s Disease;  Yuzuru Imai Book 2021 The Editor(s) (if applicable) and The Author(s), under exclusive license
描述This detailed book focuses on cutting-edge methods for Parkinson’s disease (PD) research, such as the analysis of the prion-like properties of α-synuclein, mitochondrial functions related to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway related to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells), deep brain stimulation therapy, classic mitochondrial toxins related to PD, and genetic associations and screenings using mammalian and invertebrate genetic models of PD. The collection intends to serve as an introductory protocol book for basic research on PD pathogenesis. Written for the highly successful .Methods in Molecular Biology. series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.?.Authoritative and practical, .Experimental Models of Parkinson‘s Disease. is an ideal guide for researchers continuing to work toward making PD risk predictable and surmountable..
出版日期Book 2021
關(guān)鍵詞PD development; α-Synuclein; Cellular models; Mammalian models; Invertebrate models; Neurodegenerative di
版次1
doihttps://doi.org/10.1007/978-1-0716-1495-2
isbn_softcover978-1-0716-1497-6
isbn_ebook978-1-0716-1495-2Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
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Electron Microscopic Analysis of α-Synuclein Fibrilsnd α-syn fibrils extracted from the brains of patients with MSA at the atomic level. In this chapter, we describe negative staining and immunoelectron microscopy protocols for ultrastructural characterization of synthetic α-syn fibrils and pathological α-syn fibrils.
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