Titlebook: Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis; Graham A. W. Rook,Christopher A. Lowry Book 2022 The Editor(s) (if a

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https://doi.org/10.1007/978-3-030-91051-8hygiene hypothesis; microbiota; natural environment; biodiversity; Old Friends Hypothesis; immunoregulati

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Ausgangslage und Problemstellung,atural environments can protect children from developing asthma and allergic diseases. Many environmental exposures, be it from plants, animals, parasites, or microbial sources, are likely to contribute to protection, but the underlying pathways have not been fully understood. While involvement of t

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https://doi.org/10.1007/978-3-663-02421-7d central nervous systems. We therefore need to maintain essential microbial exposures, but this is often thought to conflict with the need to maintain hygiene to avoid disease-causing pathogens. This chapter suggests a framework for solving this conundrum. First, an evolutionary approach illuminate

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https://doi.org/10.1007/978-3-663-09975-8 prime our immune systems. In many urbanised, western countries, there has been a loss of contact with these biodiverse environmental microbiota, which might be associated with the increased burden from diseases such as asthma, allergies, and autoimmune disorders. Here we summarise our growing under

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