Titlebook: Estrogens, Progestins, and Their Antagonists; Functions and Mechan Edward J. Pavlik Book 1997 Springer Science+Business Media New York 1997

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As a Model System to Study Steroid Hormone Receptorss, 1988). The cloning of the cDNAs for these receptors — ER in 1986 (Green et al, 1986) and hPR in 1987 (Misrahi et al, 1987) — and their subsequent expression in heterologous cell types permitted the reconstitution of hormone-responsive transcription systems that have been amenable to genetic analy

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New Models and Insights in Steroid Hormone Actionroid hormone action and identify new research areas that may increase our understanding of steroid hormone regulation. Recently, with available immunological and molecular tools, extensive research has focused on the structural aspects of steroid receptors, as well as on the interaction of receptors

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A Role for Progesterone in Multidrug Resistancemainstays of treatment is chemotherapy. However, a major problem in the treatment of most malignancies is the development of resistance to chemotherapeutic agents. Initially, many believed that the mechanisms of resistance to cancer chemotherapeutic agents were similar to those described for antibio

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Facilitated Binding of Steroid Hormone Receptors to Target DNA by the Chromatin High-Mobility Group rowth and progression of a high proportion of breast cancers,. are mediated by specific receptors. that are members of the nuclear receptor gene family. In addition to receptors for the sex steroid hormones and glucocorticoids, the gene family also includes receptors for thyroid hormone (TR), vitami

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