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Titlebook: Estrogen Receptor and Breast Cancer; Celebrating the 60th Xiaoting Zhang Book 2019 Springer Nature Switzerland AG 2019 estrogen receptor.br

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發(fā)表于 2025-3-21 16:44:12 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Estrogen Receptor and Breast Cancer
副標(biāo)題Celebrating the 60th
編輯Xiaoting Zhang
視頻videohttp://file.papertrans.cn/316/315806/315806.mp4
概述Written by World Renowned Leaders of the Estrogen Receptor and Breast Cancer Field to Celebrate the 60th Anniversary of the Discovery of Estrogen Receptor.Provides Comprehensive and Most Up-to-Date In
叢書名稱Cancer Drug Discovery and Development
圖書封面Titlebook: Estrogen Receptor and Breast Cancer; Celebrating the 60th Xiaoting Zhang Book 2019 Springer Nature Switzerland AG 2019 estrogen receptor.br
描述.The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insig
出版日期Book 2019
關(guān)鍵詞estrogen receptor; breast cancer; targeted therapies against ER pathways; Tamoxifen; molecular functions
版次1
doihttps://doi.org/10.1007/978-3-319-99350-8
isbn_softcover978-3-030-07593-4
isbn_ebook978-3-319-99350-8Series ISSN 2196-9906 Series E-ISSN 2196-9914
issn_series 2196-9906
copyrightSpringer Nature Switzerland AG 2019
The information of publication is updating

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https://doi.org/10.1007/978-3-031-29624-6r recruitment and selectivity, translating to varying degrees of receptor modulation and downstream functional effects. Dissecting these conformational state fluctuations within the context of variable cofactor profiles in different tissues, PTM induction, and emergence of hormonal treatment-related
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Cultural and Creative Mural Spacesne resistance include alterations of ER coregulators and pioneer factors, and genetic aberrations of ER itself. Recent advances in our understanding of the mechanisms of endocrine resistance, mostly provided by large-scale sequencing studies, further establish the roles of epigenetic alterations, th
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Book 2019e, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insig
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The Estrogen-Regulated Transcriptome: Rapid, Robust, Extensive, and Transient,athways, impacting transcriptional programs and clinical outcomes in breast cancer. This chapter reviews the key features of ERα-regulated transcription and the current technological advances that have allowed for the careful dissection of these mechanisms.
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Structural Insights into Estrogen Receptors and Antiestrogen Therapies,r recruitment and selectivity, translating to varying degrees of receptor modulation and downstream functional effects. Dissecting these conformational state fluctuations within the context of variable cofactor profiles in different tissues, PTM induction, and emergence of hormonal treatment-related
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Endocrine Disrupting Chemicals and Breast Cancer: The Saga of Bisphenol A,ogen whose adverse health effects have attracted considerable attention by scientists, industry, regulatory agencies, and the public at large. The disparate positions on health hazards by BPA, which have been undertaken by the chemical and food industries, environmental advocacy groups, health organ
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2196-9906 in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insig978-3-030-07593-4978-3-319-99350-8Series ISSN 2196-9906 Series E-ISSN 2196-9914
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