Titlebook: Essentials in Fermentation Technology; Aydin Berenjian Textbook 2019 Springer Nature Switzerland AG 2019 upstream.bioprocess engineering.d

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Solid-State Cultivation Bioreactors,as been used for centuries in the production of traditional fermented foods, most biotechnological products are currently produced by submerged culture. However, SSC will become of increasing importance for processing solid residues in biorefineries, especially when filamentous fungi are involved. T

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Bioreactors Operating Conditions,o alcohol and carbon dioxide. Later, the word was related to microorganisms, due to the demonstration of the role of yeasts by Pasteur, and in the following decades became more related to enzymes. The term fermentation is associated with the metabolic process in which an organic substrate undergoes

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Bioreactor Scale-Up,ied, to a larger scale. Scale-up is perhaps one of the hardest and most complex steps of any fermentation process for engineers. Engineers must take into account all aspects that affect the integrity of the fermentation during the scale-up process. These aspects include physical (namely, heat and ma

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Cell Separation and Disruption, Product Recovery, and Purification,to obtain the final biological product in its desired purity and concentration level. Downstream processing of a biological product consists of multiple steps of individual physicochemical operations. These operations are integrated into a sequence to yield an optimal product recovery scheme. Downst

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Bioprocess Simulation and Economics,d biotech processes. Given a product and a desired annual production rate (process throughput), bioprocess simulation endeavors to answer the following and other related questions: What are the required amounts of raw materials and utilities needed for a single batch? What are the required sizes of