Titlebook: Essential and Non-essential Metals; Carcinogenesis, Prev Anuradha Mudipalli,Judith T. Zelikoff Book 2017 The Editor(s) (if applicable) and

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Calcium Channels and Pumps: Importance During Lactation as Potential Targets for Breast Cancer,od supply into milk occurs through mammary alveolar epithelial cells. Recent research has provided deep mechanistic insight into these processes with candidates for the critical pathways involved in calcium transport identified. These proteins include the store-operated Ca. entry component Orai1 (ba

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Selenium: Roles in Cancer Prevention and Therapies, active sites in selenoproteins. In humans, 25 selenoproteins have been identified, and most of them function as important antioxidant enzymes and play important roles in the detoxification of reactive oxygen species (ROS). Selenoproteins are critical for normal physiology. Dysregulation and malfunc

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Zinc and Zinc-Dependent Proteins in Cancer and Chemotherapeutics,tic concentrations and appropriate subcellular distributions of Zn within cells, as well as the structural and catalytic roles Zn plays for many important enzymes. The mechanisms and factors by which homeostatic levels of intracellular Zn are maintained are discussed, as well as means by which Zn is

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Arsenic Carcinogenesis,on of contaminated drinking water or food, or by inhalation of fumes from burning coal. Arsenic does not induce point mutations like a classic DNA-damaging mutagen. The carcinogenic mechanism is unclear, but evidence exists supporting DNA repair inhibition, stem cell expansion, reactive oxygen gener

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Mechanisms of Nickel Carcinogenesis,manufacturing of stainless steel, jewelry, coins, batteries, and medical devices. Despite tremendous economic values, exposure to this carcinogenic metal either through acute dermal contact or chronic inhalation in occupational settings can elicit a wide range of health problems including contact de

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Book 2017n, experimental and mechanistic data, as well as a detailed analysis into the modes of actionfor different cancer outcomes will be discussed in each chapter wherever deemed feasible. These approaches are ones in which no other book in this area has attempted to do..