Titlebook: Essential Concepts in Toxicogenomics; Donna L. Mendrick,William B. Mattes Book 2008 Humana Press 2008 Annotation.Biomarkers.Genomic data.M

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Miron Ya. Amusia,Larissa V. Chernyshevaectors of the scientific community. They are particular well suited for tackling some of the questions encountered in the field of toxicogenomics, where the number of studies and microarray analyses would be prohibitively expensive for a single organization to carry out. Five consortia that stand ou

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Computation of Curves and Surfacesstics of a steady pipeline of agents advancing toward clinical testing. Applications of toxicogenomics to the evaluation of compounds could best be realized if this promising technology could be implemented in these studies fully anchored in the traditional study end points currently used to charact

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Toxicogenomics and Classic Toxicology: How to Improve Prediction and Mechanistic Understanding of He ways to improve their productivity and supplement their classic toxicology studies. Acceptance of toxicogenomics will continue to grow as regulatory concerns are addressed, proof of concept studies are disseminated more fully, and internal case studies show value for the use of this new technology in concert with classic testing.

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1064-3745 rofit organizations and academia.Covers the many uses of tox.The field of toxicogenomics has been growing quickly,?yet with rapid growth comes the need to periodically reflect on the nature of the field.? .Essential Concepts?in Toxicogenomics. collects reviews, opinion pieces and case studies from t

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Vijay Gupta,Michael Th. Rassiasvide validated and reliable information about the toxicity of compounds. In addition, we provide study design recommendations for genomic studies in toxicology, covering areas of power, sample size, the need for replicates, and the issue of sample pooling.

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Computation in Neurons and Neural Systems follow such injury in both preclinical and clinical settings. This chapter will explore some of the issues surrounding the use of pharmacogenomics to identify and qualify such biomarkers, and examples will be provided.

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https://doi.org/10.1007/978-3-540-68547-0derstanding the mechanism of toxicity for a compound is a critical step in forming a rational plan for developing counterscreens for toxicity and for increasing productivity of research and development while decreasing the risk of late-stage failure in pharmaceutical development.

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Use of Traditional End Points and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogederstanding the mechanism of toxicity for a compound is a critical step in forming a rational plan for developing counterscreens for toxicity and for increasing productivity of research and development while decreasing the risk of late-stage failure in pharmaceutical development.