Titlebook: Erythrocytes as Drug Carriers in Medicine; Ulrich Sprandel,James L. Way Book 1997 Springer Science+Business Media New York 1997 blood.clin

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Organophosphorus Antagonism by Resealed Erythrocytes Containing Recombinant Paraoxonase,protection greatly exceeds any antidotal regimen ever reported against chemical toxicants. The present drug carrier model provides a general conceptual approach to develop specific antidotes against many other chemical toxicants for which no antidotes are presently available.

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Biochemical Properties of Alcohol Dehydrogenase and Glutamate Dehydrogenase Encapsulated into Humanhyde by ADH-RBCs, as a function of time (up to 72h), suggest the use of these carrier RBCs to fully metabolize ethanol. The rapid utilization of ammonia in the presence of GDH-RBCs suggest the use of these RBCs as carrier systems. These properties open the possibility of using ADH- and GDH-RBCs as carrier systems under . situations.

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Binding of Daunorubicin and Doxorubicin to Erythrocytes Treated with Glutaraldehyde,dily released from these erythrocytes in the antibiotic-free medium. Our findings provide evidence that immobilization of anthracycline antibiotics in the erythrocytes using glutaraldehyde treatment is connected with the chemical binding of the antibiotics to different erythrocyte components.

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d is due to a deficiency of glucocerebrosidase. An absence of glucocereobrosidase results in an accumulation of glucocere-broside within the macrophages of the reticulo-endothelial system in the spleen, liver and bone marrow to produce Gaucher cells which are characteristic of this disorder.