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Titlebook: Epstein-Barr Virus and Human Disease · 1990; D. V. Ablashi,A. T. Huang,Kristin? L. Ablashi Book 1991 Springer Science+Business Media New Y

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書目名稱Epstein-Barr Virus and Human Disease · 1990
編輯D. V. Ablashi,A. T. Huang,Kristin? L. Ablashi
視頻videohttp://file.papertrans.cn/314/313407/313407.mp4
叢書名稱Experimental Biology and Medicine
圖書封面Titlebook: Epstein-Barr Virus and Human Disease · 1990;  D. V. Ablashi,A. T. Huang,Kristin? L. Ablashi Book 1991 Springer Science+Business Media New Y
描述The Epstein-Barr virus (EBV), isolated in 1966, continues to draw worldwide attention as an important human pathogen. Its impor- tance is largely related to the continuing accumulation of evidence that implicates EBV as an etiological factor for certain types of human cancer. More recent investigations on this virus have focused on the identity of the viral genes responsible for the different disease mani- festations observed following viral infection. It is hoped that by thorough investigation of this virus, clues to how cancer develops from a normal cell will surface. In addition, many of the gene products are now being exploited for the development of new and more sensitive tests for the diagnosis and clinical management of individu- als with EBV -associated diseases. Thus, studies on this virus continue to provide new information of importance to our understanding of the malignant process. In an effort to attract both basic and clinical scientists to the same meeting for purposes of scientific exchange and fostering a closer interaction between these individuals, a series of international symposia was initiated in 1984. The first meeting was held in Loutraki, Greece, and was at
出版日期Book 1991
關鍵詞DNA; Promoter; Translation; cell lines; genes; molecular biology; transcription
版次1
doihttps://doi.org/10.1007/978-1-4612-0405-3
isbn_softcover978-1-4612-6747-8
isbn_ebook978-1-4612-0405-3
copyrightSpringer Science+Business Media New York 1991
The information of publication is updating

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Overview of Patient Data Anonymization, of the posttranscriptional MS regulator (2,6) consequently leading to the cascade-like lytic pattern. We analysed the MS promoter and upstream element for its responsiveness to EBV trans-activators or TPA in different cell types and investigated its dependence to the stage of cell differentiation.
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Replication of the Epstein-Barr Virus in Lymphoid and Epithelial Cells (ccc) episome. After induction of replication, the episomal DNA seems to serve as template for generation of the linear, virion DNA, which is synthesized by a viral-specific DNA polymerase, in contrast to the episomal form which is maintained by the cellular DNA polymerase [3].
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EBNA-2 Transactivation of LMP12) is one of the first genes expressed following primary B lymphocyte infection, in vitro (2, 3, 4, 5). EBNA-2 transactivates expression of LMP1 (6 ,7); and upregulates expression of cellular genes including CD23 (8, 9), CD21 (9, 10), and cfgr (11).
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Relationship of the EBV Lytic Activator Zta to the bZIP Family of Cellular Transactivators (3 copies). These sites resemble the AP-1 binding site (TGAGTCA) for the Jun/Fos cellular transcription factors and Zta binds equally well to an AP-1 site as a ZRE site (2,3). The sites identified not only bind Zta but when cloned into a normally non-responsive target, for example TK-CAT or A10-CAT, confer Zta responsiveness on these targets (2).
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