Titlebook: Epigenetics in Cardiac Disease; Johannes Backs,Timothy A. McKinsey Book 2016 Springer International Publishing Switzerland 2016 Cardiac de

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Histone Methylation in Heart Development and Cardiovascular Disease,cal stresses. In this review, we describe basics of histone methylation, and current body of literature on the role of several common histone methylations and their modifying enzymes in cardiovascular development, congenital and adult heart diseases.

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The Lysine Acetyltransferases in Cardiovascular Disease,es of mammalian KATs: GNAT, p300/CBP, MYST, and the nuclear receptor coactivators, including CLOCK. Several additional KATs that to date have not been structurally analyzed will also be considered. Special attention will be paid to the role of the KATs in human genetic disorders and in processes important to cardiac and vascular biology.

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Epigenetic and Nongenomic Roles for Histone Deacetylases in Heart Failure, enzymes, histone deacetylases (HDACs), represent such nodal points. We discuss recent findings that illustrate how HDACs not only control cardiac gene expression via epigenetic regulation, but also serve crucial non-genomic functions in the heart through deacetylation of non-histone proteins.

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Mhc-Molecule

Sirtuins as Regulators of Cardiac Hypertrophy and Heart Failure, transcription and fitness of mitochondria. Many sirtuin isoforms have been also studied for their roles in regulating cardiac development and protecting the heart from pathological stress. In this review, we will discuss impact of sirtuins in overall health of the cardiovascular system.

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Epigenetics: Chromatin Organization and Function,sion but are not dependent on alterations in DNA sequence. Herein, we review histone PTMs, histone variants and DNA modifications in the functioning of the nucleosome as an epigenetic signalling module. The majority of the human genome is transcribed, with most of the genome producing non-coding RNA

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