Titlebook: Epigenetic Alterations in Oncogenesis; Adam R. Karpf Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to

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Ten Eleven Translocation Enzymes and 5-Hydroxymethylation in Mammalian Development and Cancerlthough 5hmC was discovered several decades ago, it was only after its recent identification in murine brain and stem cell DNA that it has become a major focus of epigenomic research. Part of the reason for this delay is due to the difficulty in detecting both global and locus-specific 5hmC levels.

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Altered Histone Modifications in Cancerin coding genes. These actions are central to human health and are evidently aberrant in cancer. Central components of regulated gene expression are a variety of epigenetic mechanisms that include histone modifications. The post-translational modifications of histones are widespread and diverse, and

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Nucleosome Occupancy and Gene Regulation During Tumorigenesiscert with other epigenetic mechanisms (such as DNA methylation, histone modifications, changes in histone variants, as well as small noncoding regulatory RNAs) play essential roles in the control of gene expression. Here, we discuss the mechanisms and factors that regulate nucleosome position and ge

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Epigenetic Regulation of miRNAs in Cancerme regulatory epigenetic processes of protein coding genes. In turn, a specific subgroup of miRNAs, called epi-miRNAs, is able to directly target key enzymatic effectors of the epigenetic machinery (such as DNA methyltransferases, histone deacetylases, and polycomb genes), therefore indirectly affec

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DNA Hypomethylation and Activation of Germline-Specific Genes in Cancers become profoundly altered in cancer cells: both gains (hypermethylation) and losses (hypomethylation) of methylated sites are observed. Although DNA hypomethylation is detected in a vast majority of human tumors and affects many genomic regions, its role in tumor biology remains elusive. Surprisin

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Epigenetic Changes During Cell Transformationmental inputs participate in driving the epigenetic changes that occur during human carcinogenesis. The pathologic changes seen in DNA methylation and histone posttranslational modifications are complex, deeply intertwined, and act in concert to produce malignant transformation. To better understand

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