Titlebook: Enzyme-Prodrug Strategies for Cancer Therapy; Roger G. Melton,Richard J. Knox Book 1999 Springer Science+Business Media New York 1999 bioc

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Phage Technology for Producing Antibody-Enzyme Fusion Proteins,e of ADEPT systems is that they potentially include an amplification step (each enzyme molecule produces many molecules of the active drug within the tumor) and a bystander effect (destruction of neighboring cells and those binding the antibody fragment) because the final cytotoxic molecule is produ

尖酸一點

最初

https://doi.org/10.1007/978-1-349-17617-5e of ADEPT systems is that they potentially include an amplification step (each enzyme molecule produces many molecules of the active drug within the tumor) and a bystander effect (destruction of neighboring cells and those binding the antibody fragment) because the final cytotoxic molecule is produ

心神不寧

Introduction,elves and have proved very difficult to overcome. To date, there have been numerous attempts to improve the cytotoxicity of the antibody “missile” by attaching a variety of “warheads” to them, for example, cytotoxic drugs, such as adriamycin or methotrexate, toxins, such as ricin A-chain or . exotoxin, and radioisotopes (.).

多嘴多舌

多嘴多舌

Schlemms-Canal

VOC

Enzymes and Prodrugs Used for ADEPT,out a hundredfold the equivalent of a normal clinical dose of present day agents. However, this cannot be achieved because of the toxic effect on the normal most rapidly dividing host tissues, such as bone marrow, gut mucosa, and the lymphatic system.

挫敗

The Design and Synthesis of Prodrugs for Antibody-Directed Enzyme Prodrug Therapy (ADEPT),toxic prodrug is administered which releases a therapeutic drug on contact with the enzyme. This two-step approach has the potential to overcome many of the limitations of current chemotherapeutic strategies, allow the generation of high intratumoral concentrations of drug, and minimize damage to normal tissues.