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Titlebook: Enzyme Kinetics in Drug Metabolism; Fundamentals and App Swati Nagar,Upendra A. Argikar,Donald J. Tweedie Book 2014 Springer Science+Busine

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發(fā)表于 2025-3-21 18:28:53 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Enzyme Kinetics in Drug Metabolism
副標題Fundamentals and App
編輯Swati Nagar,Upendra A. Argikar,Donald J. Tweedie
視頻videohttp://file.papertrans.cn/314/313091/313091.mp4
概述Includes clear explanations of fundamentals for correct application.Contains key notes, experiences and implementation advice from.Covers relevant and current topics including Drug Metabolizing Enzyme
叢書名稱Methods in Molecular Biology
圖書封面Titlebook: Enzyme Kinetics in Drug Metabolism; Fundamentals and App Swati Nagar,Upendra A. Argikar,Donald J. Tweedie Book 2014 Springer Science+Busine
描述.Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. .Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications. focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful .Methods in Molecular Biology. series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross re
出版日期Book 2014
關鍵詞drug metabolism; drug transporters; enzyme kinetic models; enzyme kinetics; kinetic analysis; transporter
版次1
doihttps://doi.org/10.1007/978-1-62703-758-7
isbn_softcover978-1-4939-6046-0
isbn_ebook978-1-62703-758-7Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC 2014
The information of publication is updating

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https://doi.org/10.1007/978-1-349-20065-8metabolism, kinetics of depletion of substrates (endogenous or exogenous) and formation of metabolites deals with the rate of metabolism. The current textbook specifically focuses on kinetics of drug-metabolizing enzymes, detailing specific enzyme classes, and discusses kinetics as they apply to dru
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Impacts of Climate Change in Africa,ombinant enzyme systems utilized in drug metabolism, each of these has different components that can influence the free drug concentration. The physicochemical properties of the test compound are also paramount in determining the influential factors in any deviation between true and apparent kinetic
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Leon Mwamba Tshimpaka,Samuel Ojo Oloruntobage of substrate concentrations, the rate of product formation initially increases as substrate concentration increases, then decreases at high substrate concentrations, i.e., they exhibit substrate inhibition or partial substrate inhibition. This chapter gives an introduction to sulfotransferases, i
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African Air Transport Managementof multiple initial drug concentrations and multiple time points at each concentration, until steady state is reached between P-gp-mediated efflux into the apical chamber and passive permeability from apical chamber back into the cytosol. Although this model optimally requires a larger than usual da
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