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Titlebook: Entry Inhibitors in HIV Therapy; Jacqueline D. Reeves,Cynthia A. Derdeyn Book 2007 Birkh?user Basel 2007 AIDS.HIV.HIV Therapy.HIV infectio

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發(fā)表于 2025-3-21 19:08:55 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Entry Inhibitors in HIV Therapy
編輯Jacqueline D. Reeves,Cynthia A. Derdeyn
視頻videohttp://file.papertrans.cn/312/311883/311883.mp4
概述The impact of viral sequence diversity on this class of inhibitors is discussed.Connection between basic research and clinical studies is shown.Focuses on real-world issues, such as virus phenotyping
叢書名稱Milestones in Drug Therapy
圖書封面Titlebook: Entry Inhibitors in HIV Therapy;  Jacqueline D. Reeves,Cynthia A. Derdeyn Book 2007 Birkh?user Basel 2007 AIDS.HIV.HIV Therapy.HIV infectio
描述.Entry Inhibitors in HIV Therapy details the current status of this relatively new and very dynamic class of inhibitors, appealing to both the clinician and basic research scientist. A unique overview of obstacles and accomplishments is presented. The book features chapters that explain the challenges of high sequence diversity in the viral envelope gene for the development and use of entry inhibitors, the clinical utility of virus phenotyping, the development of this class of inhibitors as microbicidal therapy, and the success story of enfuvirtide from the bench to FDA approval. Both basic research findings and results of clinical studies are covered and linked together by a diverse panel of experts in the field..
出版日期Book 2007
關(guān)鍵詞AIDS; HIV; HIV Therapy; HIV infection; development; drug; drug development; glycoprotein; immunodeficiency; i
版次1
doihttps://doi.org/10.1007/978-3-7643-7783-0
isbn_ebook978-3-7643-7783-0Series ISSN 2296-6056 Series E-ISSN 2296-6064
issn_series 2296-6056
copyrightBirkh?user Basel 2007
The information of publication is updating

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Inhibitors that target gp120 interactions with coreceptor,ssays on human cell lines as syncytium inducing (SI) or non-syncytium inducing (NSI) [.]. NSI viruses predominate early after transmission, are capable of growth in primary macrophages (macrophage tropism), and fail to grow in most established human T cell lines. SI viruses, by contrast, are found i
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Entry inhibition of HIV-1 subtype C isolates, [.]. There is less information on how genetic variability might affect the efficacy of a newer class of anti-retrovirals, the entry or fusion inhibitors. This group comprises a diverse collection of compounds that target both viral and host cell components blocking virus attachment and/or fusion an
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Future clinical prospects for entry inhibitors,once (with the FDA approval of a membrane fusion inhibitor, enfuvirtide, in 2003) has this strategic approach resulted in a commercially available agent. Indeed, for more than 15 years, from 1987 to 2003, all available antiretroviral therapies targeted one of two HW-encoded enzymes, reverse transcri
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