Titlebook: Engineering in Translational Medicine; Weibo Cai Book 2014 Springer-Verlag London 2014 Engineering of Clinical Imaging Systems.Nanoenginee

漂白

慌張

Engineering T Cells to Target Tumor Cells conditional elimination if they induce an unintended immune response or transform to a malignant phenotype. In this chapter, we describe the current status of adoptive therapy for cancer with genetically engineered T cells.

花費(fèi)

Engineering Biomaterials for Anchorage-Dependent and Non-anchorage-Dependent Therapeutic Cell Deliveon-anchorage-dependent cells (non-ADCs) such as chondrocytes and hepatocytes do not and often exhibit a rounded morphology in native environment. Here, the different cell delivery structures and their development in delivering both ADCs and non-ADCs are discussed.

臆斷

Terrace

Alternative Protein Scaffolds for Molecular Imaging and Therapye, production, and/or conjugation. Validated scaffolds include the fibronectin domain, knottin, designed ankyrin repeat protein, anticalin, and affibody among others. These scaffolds have demonstrated efficacy in preclinical animal models and, in some cases, clinical trials in therapy or imaging. Th

interpose

Engineering Multivalent and Multispecific Protein Therapeuticsthrough avidity effects, and selectivity for a diseased versus normal state. These aspects lead to greater therapeutic control over an intended biological response, with the potential for reduced side effects. In this chapter, we describe the basic biophysical principles underlying multivalency and

DAUNT

Engineering Aptamers for Biomedical Applications: Part Iment of aptamer-based biosensors and have pushed them closer to clinical applications. In this chapter, we will detail the recent development in engineering aptamers and highlight the work for sensor applications by using engineered aptamers.

Liability

Engineering Aptamers for Biomedical Applications: Part IIased therapeutics. As such, aptamers couple the advantages of the specific binding of monoclonal antibodies to the chemical nature of nucleic acids. Here, we will focus on the development of multifunctional aptamer-based bioconjugates for targeted delivery of therapeutics and imaging agents to disea

intricacy

Engineering DNA Vaccines for Cancer Therapyss engineering efforts to enhance the immune and anti-tumor efficacy of DNA vaccines, focusing on specific changes that can be made to the DNA backbone to enhance the expression, processing, and presentation of the encoded antigen, as well as improving the inherent immunogenicity of the vaccine itse

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