Titlebook: Endotoxin Induced-Shock: a Multidisciplinary Approach in Critical Care; Silvia De Rosa,Gianluca Villa Book 2023 The Editor(s) (if applicab

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Pathophysiology of Endotoxic Shock,the bacterial cell. It is recognized as a pathogen-associated molecular pattern and its recognition by pattern recognition receptors activates the inflammatory response. The consequent release of proinflammatory cytokines and chemokines triggers the classical manifestations of the antimicrobial and

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Host Resistance to Endotoxic Shock,endotoxin exposure may induce a state of immunosuppression, namely “endotoxin tolerance,” that balances hyperinflammation and may protect the host from the development of endotoxic shock. In this setting, endotoxin tolerance may be considered a model of epigenetic modification and complex gene repro

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Endotoxin and Organ Cross-Talk,auses of mortality and morbidity in intensive care units worldwide. The emergence of progressively multidrug-resistant pathogens and the gradual drying up of the antibiotic pipeline have led the fight against pathogens to reach critical proportions. Sepsis results from a heterogeneous interaction of

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Clinical Management of Endotoxemia: Antibiotics,ntervention may be associated with potential harms as well as challenged by concurrent patient and pathogen characteristics that may limit its efficacy. For these reasons, antimicrobic choice should be driven by evidence-based stewardship programs that take into account the severity of organ dysfunc

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Clinical Management of Endotoxemia: Volume Support,s a key role in endotoxic shock, with the aim of balancing resuscitation thus avoiding additional harm. Many types of solutions are available for fluid administration. Currently, some study groups promote the use of intravenous . solutions whilst chloride administration may impact on renal function

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Clinical Management of Endotoxemia: Source Control,l may include drainage of an abscess, debriding infected necrotic tissue, removal of a potentially infected device, or definitive control of a source of ongoing microbial contamination. The timing and adequacy of source control are important in the management of intra-abdominal infections; late and/