Titlebook: Endothelial Signaling in Development and Disease; Mirko HH Schmidt,Stefan Liebner Book 2015 Springer Science+Business Media New York 2015

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Fibroblast Growth Factor Signaling in Vascular DevelopmentFGF receptors and the regulatory mechanisms involved in their function; and (iii) to recapitulate the available experimental data regarding the mechanism of action of FGFs, and to discuss their role in embryonic vascular development.

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The Vasculature in the Diseased Eyeed human eye disease, they reflect the complex hyperglycemia-driven interaction of the neurovascular unit better than any in vitro systems. Downstream of high ambient glucose, multiple biochemical abnormalities exist which affect not only vascular cells of the capillary network but the entire neurov

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Oxygen Signaling in Physiological and Pathological Angiogenesisailability. Inhibition of these oxygen-sensing enzymes, and thus preadaptation of endothelial cells to hypoxic conditions, is linked to a beneficial outcome in disease conditions. In this chapter, we will discuss the molecular basis of oxygen sensing, how this response impacts on the endothelial cel

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Vascular Development in the Zebrafishized tubes permits circulation of blood while enabling the exchange of oxygen and nutrients in all perfused tissues. Recent studies in zebrafish have provided additional insight into the initial establishment of the vasculature, particularly the process of vasculogenesis. During vasculogenesis, angi

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Fibroblast Growth Factor Signaling in Vascular Developmentthelial cell growth and migration both . and ., and have, alongside vascular endothelial growth factor, long been considered as the principal angiogenic factors in tumor development. Due to their potency, FGFs (and, foremost, FGF-2/basic FGF) are routinely used by numerous laboratories as proangioge