Titlebook: Endogenous Stem Cell-Based Brain Remodeling in Mammals; Marie-Pierre Junier,Steven G. Kernie Book 2014 Springer Science+Business Media New

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https://doi.org/10.1007/978-1-4613-4419-3ry real potential of cell-based therapies as a compelling choice for regenerative medicine. In the central nervous system, where cellular specialization is so diverse, this mode of therapy is particularly attractive. However, as more is becoming known about the intrinsic repair capabilities of the b

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https://doi.org/10.1007/978-1-4899-3754-4ring development. This mechanism has been demonstrated following neonatal hypoxia or hypoxia–ischaemia. In contrast, systemic inflammation seems to inhibit neural stem/progenitor cell proliferation. The impact of seizures and trauma on neural stem/progenitor cell proliferation is more complex and ap

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Michiaki Iwata,Kenji Umemura,Naoki Midohury remains largely unknown. In addition, glial-specific progenitors appear to be quite widespread throughout the brain, and their roles in injury-induced remodeling are also just beginning to emerge. Ongoing adult neurogenesis occurs in two regions of the mammalian brain—the subventricular zone (SV

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Shoshi Kikuchi,Guo-Liang Wang,Lei Lich new neurons and glial cells differentiate from neural stem/progenitor cells and functionally integrate into existing cellular networks and contribute to their functions. Besides the two well-established neurogenic areas of the mammalian brain, the subventricular zone of the lateral ventricles and

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Pathogen Recognition and Immune Signaling, (CNS). NG2 cells are mostly known for their role as oligodendrocyte progenitor cells (OPCs) and have been shown to generate most if not all oligodendrocytes and myelin, both during development and after a demyelinating injury. It has also been proposed that NG2 cells could play additional roles in

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https://doi.org/10.1007/978-3-030-66530-2t of IVH results in remodeling of the periventricular germinal matrix and the white matter. The onset of hemorrhage initiates a cascade of events, including inflammation, microglial activation, astrocytosis, and degeneration along with arrested maturation of oligodendrocytes. These processes contrib

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https://doi.org/10.1007/978-94-017-9535-7equired for accessing fetal cells preclude its extension to the relevant population of patients. Pluripotent stem cell derivatives offer an alternative source of cells for regenerative medicine. However genomic alterations may occur in culture and compromise their proper use in therapy. Recurrent ch

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