Titlebook: Endocrinology of the Testis and Male Reproduction; Manuela Simoni,Ilpo T. Huhtaniemi Reference work 2017 Springer International Publishing

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Control of GnRH Secretionugh the lifespan is not completely understood, but is clearly the result of a sophisticated network of stimulatory and inhibitory inputs, that include centrally different subgroups of neurons afferent to the GnRH-secreting neurons and peripherally the gonadal steroid feedback. The present chapter of

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Gonadotropin Receptorsranulosa cells. LHCGR activation stimulated Leydig cell steroidogenesis, in particular testosterone production, while FSHR maintains Sertoli cell metabolism, thereby indirectly stimulating spermatogenesis. Recent basic research, using GnR, expressing cells in vitro and genetically modified mice in v

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Sex Determinationmale-specific program) ensues in the absence of . expression during a critical developmental time window. In this chapter, we will cover the processes of gonad specification and sex determination, focusing on major factors and signaling pathways involved in the male-versus-female decision and the es

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Testis Development and Descentys has grown over the past few years, and novel players involved in sexual development, such as epigenetic regulators, have arisen..Enlightenment of these networks is critical for a better characterization of conditions such as disorders of sex development (DSD), infertility, and gonadal cancer.

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