Titlebook: Emerging Therapeutic Targets in Ovarian Cancer; Stan Kaye,Robert Brown,Martin Gore Book 2011 Springer Science+Business Media, LLC 2011

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Maheshwar Sharon,Madhuri Sharonc compounds led by the confirmation of bevacizumab as a key component of front-line therapy in advanced colorectal cancer in 2004. Ovarian cancer is one of only a few solid tumours that responds to single-agent anti-VEGF therapy. VEGF inhibitors are also active when administered in combination with

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French Nuclear Command and Control,abolism and survival. In ovarian cancer, alterations have been observed in both the catalytic and regulatory subunits of the PI3K enzyme, in the opposing phosphatase PTEN and in each of the three isoforms of AKT itself. The net effect is a frequent hyperactivation of the pathway which has been linke

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https://doi.org/10.1007/978-90-481-3411-3nesis with indirect effects exerted through VEGF. Additional potent pro-angiogenic cytokines such as IL-6 and IL-8 act via Src as well. Src also directly affects vascular permeability by impacting endothelial cadherin function, thereby inducing vascular leakage of tumor and interstitial fluid. Furth

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Nuclear Data for Science and Technologyutation carriers and 10–20% for . carriers The analysis of . and . function in DNA repair is leading to new approaches to antitumour therapy for such patients, including the use of poly(ADP)-ribose polymerase (PARP) inhibitors. Such novel agents are selectively lethal to cells lacking functional . o

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https://doi.org/10.1007/978-3-642-87663-9alignant disease have had varying levels of success in the treatment of patients with ovarian cancer. This chapter will discuss in depth the following cell membrane receptors and proteins: integrins, the EGFR/HER family of receptors, IGF receptors, c-Met, and will mention cadherins and the transform

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Specific Measurements, Units and Terms. Such epigenetic mechanisms include DNA methylation, post-translational modifications of histones and non-coding RNAs. All types of ovarian cancer show wide-spread aberrant epigenetic changes, leading to changes in expression of genes involved in all the hallmarks of cancer, as well as genes involv

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The Nuclear Weapons Proliferation Issueruct the heterogeneity of the original tumor in immunocompromised mice through asymmetric cell division. As satisfying as the concept of an ovarian cancer stem cell is to explain the origins of ovarian cancer, can this concept be applied universally to explain the diversity in the histologic types o