Titlebook: Emerging Strategies in Neuroprotection; Paul J. Marangos,Harbans Lal Book 1992 Birkh?user Boston 1992 Evolution.biology.brain.neuroscience

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書(shū)目名稱Emerging Strategies in Neuroprotection被引頻次




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OCTO

Modeling Neurodegeneration and Neuroprotection in Hippocampal Slicestechnique became a useful tool in the hands of electrophysiologists and pharmacologists. Yamamoto and McIlwain (1966) were the first to show that mammalian brain (prepyriform cortex) slices maintained in vitro exhibited electrical activity comparable to that obtained in vivo. Along with cell culture

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Stroke Models for Preclinical Trials of Neuroprotective Agentsain during or following ischemic insult. Despite the numerous claims of therapeutic success in animal models in the past two decades, no therapeutic agents have been approved by the Food and Drug Administration (FDA) for patients with acute ischemic stroke in the United States (Pulsinelli and Buchan

敘述

Animal Models of Ischemiaficulty determining whether a proposed therapy is effective. Appropriate studies in patients are complex, and few animal models are adequate for realistic and efficient tests of pharmacologic methods to reduce damage or restore neurologic function. Most cerebral stroke models have not been designed

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Calcium Channel Blockers and Neuroprotectionolved within a short period of time (minutes), will lead to a core of severely ischemic tissue that may not be salvaged. However, the ultimate size of the brain infarct also depends on the “penumbra,” a zone of tissue around the core of the infarct where blood flow is still maintained above a neuron

縮短

Self-Defense of the Brain: Adenosinergic Strategies in Neurodegenerationedicine. The breadth and scope of the pathologic factors are such that, even with the improved understanding of the involved events, it is extremely difficult to decide which of them are the primary instigators of the ensuing damage and which are but secondary effects of an ongoing process of the ne

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