| 書目名稱 | EGFR Signaling Networks in Cancer Therapy | | 編輯 | John D. Haley,William John Gullick | | 視頻video | http://file.papertrans.cn/301/300376/300376.mp4 | | 概述 | Probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers.Describes EGF receptor in a tumor tissue specific context.Illustrates the man | | 叢書名稱 | Cancer Drug Discovery and Development | | 圖書封面 |  | | 描述 | The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described a | | 出版日期 | Book 2008 | | 關(guān)鍵詞 | EGFR; STAT 3; Signaling networks; angiogenesis; enzymes; glioblastoma; heterodimerization; inhibitors; kinas | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-59745-356-1 | | isbn_softcover | 978-1-61737-853-9 | | isbn_ebook | 978-1-59745-356-1Series ISSN 2196-9906 Series E-ISSN 2196-9914 | | issn_series | 2196-9906 | | copyright | Humana Press 2008 |
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