Titlebook: EGF Receptor in Tumor Growth and Progression; R. B. Lichtner,R. N. Harkins Conference proceedings 1997 Springer-Verlag Berlin Heidelberg 1

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Signal Transduction by EGF Receptor Tyrosine Kinase,st studied receptor signaling systems from this family is the epidermal growth factor receptor (EGFR). The EGFR is widely expressed in mammals and has been implicated in various stages of embryonic development. Recently, EGFR knockout mice by targeted disruption of exon 1 (Sibilia and Wagner 1995) o

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The Role of Estrogen in the Regulation of EGFR Expression, al. 1984; Sainsbury et al. 1985; Koenders et al. 1991; Sharma et al. 1992). While expression of ER usually predicts for responsiveness to endocrine therapy and overall good prognosis (Osborne et al. 1980), EGFR expression (independent of ER) correlates with lack of response to endocrine therapy, hi