Titlebook: Dynamic Hyperpolarized Nuclear Magnetic Resonance; Thomas Jue,Dirk Mayer Book 2021 Springer Nature Switzerland AG 2021 chemical shift imag

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New Insights into Metabolic Regulation from Hyperpolarized 13C MRS/MRI Studies,ated perfused rodent hearts and livers and in living animals. Even though multiple oxidizable substrates (glucose, fats, and ketones) are always available to tissues in vivo, presentation of a highly polarized substrate such as pyruvate to tissues while imaging downstream metabolic products derived

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2698-380X Understand Biochemistry from Cells to Humans??.Innovating Metabolic Biomarkers for Hyperpolarized NMR??.New Insights into Metabolic Regulation from Hyperpolarized?.13.C MRS/MRI Studies?.Novel Views on Heart Fu978-3-030-55043-1Series ISSN 2698-380X Series E-ISSN 2698-3818

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Beziehungen zwischen Situationen, underlying enzyme kinetics, and chemical exchange processes. In this chapter, we review these effects and discuss approaches currently used to quantify in vivo data. Quantitation is of particular importance for comparing results across sites and informing on the underlying pathologies.

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O,vation for several ongoing applications to pathologies in patients is also described. Finally, the role of preclinical studies for developing the best approaches for analyzing the dynamic hyperpolarized MR data and providing an understanding of the underlying biochemistry of the pathologies being st

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R,e, the by-product of the pyruvate dehydrogenase?complex. This chapter introduces normal cardiac metabolism and then highlights the challenges and methods used for cardiac metabolic imaging. Next, key studies showing physiological metabolism in the isolated perfused heart, in rodents, and in large an

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Charakterisierung von Objektbegriffens of these models. Both the glycogen shunt and intracellular lac shuttle models require rapid mobilization and utilization of lac. If lac cannot mobilize rapidly, then the results invalidate immediately the hypotheses in both models. Can muscle then use and mobilize lac? Indeed, the DNP experiment r