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Titlebook: Drug-Induced Hepatotoxicity; Ross G. Cameron,George Feuer,Felix A. Iglesia Book 1996 Springer-Verlag Berlin Heidelberg 1996 Hepatotoxizit?

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發(fā)表于 2025-3-21 19:01:02 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Drug-Induced Hepatotoxicity
編輯Ross G. Cameron,George Feuer,Felix A. Iglesia
視頻videohttp://file.papertrans.cn/284/283166/283166.mp4
叢書名稱Handbook of Experimental Pharmacology
圖書封面Titlebook: Drug-Induced Hepatotoxicity;  Ross G. Cameron,George Feuer,Felix A. Iglesia Book 1996 Springer-Verlag Berlin Heidelberg 1996 Hepatotoxizit?
描述The advances in science and medicine we are now experiencing are unprec- edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effort is made to devise medications that are safe, and the need to elucidate and understand mechanisms are crucial, yet adverse effects remain a problem. They can be unpredictable and diverse. Drugs have been shown to induce virtually the whole gamut of human liver pathology from acute fulminant hepatitis to chronic active hepatitis to cirrho- sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease.
出版日期Book 1996
關(guān)鍵詞Hepatotoxizit?t; Leber; Reye‘s syndrome; drug; hepatoxicity; liver; toxicity; hepatology; metabolic disease
版次1
doihttps://doi.org/10.1007/978-3-642-61013-4
isbn_softcover978-3-642-64657-7
isbn_ebook978-3-642-61013-4Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1996
The information of publication is updating

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Fabio Claudio Ferracchiati,Emanuele Garofalonts in the quantitative and qualitative design of drug therapy. However, this important role of the liver is a “double-edge sword.” Since the liver often converts original drugs to water-soluble forms for excretion, it must of necessity convert many an “inactive” compound to an “active” one during t
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Enjoying Music, Video, and eBooksechanisms of drug toxicity has been carried out in animal models or in vitro systems using cultures of non-hepatocyte cell lines. The limitations and pitfalls of extrapolating from non-human data to the clinical situation are well recognised.
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Connecting Monitors and Hardwareivery to the liver before the drug is distributed throughout the body and exerts its therapeutic effects, (b) trans cellular pores or fenestrations in the endothelial cells lining the sinusoidal spaces are unique to the liver and are sufficiently large to permit most plasma proteins to diffuse into
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Markup Languages: More Than HTML5tion and imprecise correlations between the observed immune response and the histopathology in affected tissues. In particular, assays in vitro in which lymphocytes are exposed to the culprit drug may be unrevealing, either because the immune response is directed to a drug metabolite present in low
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Testing Windows Phone Applications,ilure (FHF) has no vascular component. HE associated with FHF shows an acute onset with delirium progressing to deep coma. While delirium and seizures are generally uncommon in HE, they may occur during the rapid evolution of HE due to FHF (. 1986). Although some of the characteristics of HE associa
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