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Titlebook: Drug Toxicity in Embryonic Development I; Advances in Understa Robert J. Kavlock (Director),George P. Daston Book 1997 Springer-Verlag Berl

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https://doi.org/10.1007/978-1-349-19362-2potent biological activities. The basic skeleton, prostanoic acid, and a typical naturally occurring prostaglandin, prostaglandin E. (PGE.), are depicted in Fig. 1. Each prostaglandin is designated by a letter of the alphabet, A–J, according to the composition of its cyclopentane ring, and by a nume
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https://doi.org/10.1007/978-1-349-19362-2oxic intermediary metabolites. Thus, while the parent xenobiotic, or “proteratogen”, is relatively inert and non-toxic, reactive intermediates, depending upon their chemical nature, can irreversibly (“covalently”) bind to and/or oxidise embryonic molecular targets such as DNA, protein and lipid. The
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Vertebrate Limb Development secondary embryonic fields. The mature vertebrate limb contains a large number of distinct cell types that develop side by side in a highly coordinated and orchestrated manner, and it is the molecular underpinnings of this patterning mechanism that lie at the heart of our understanding of how genet
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