Titlebook: Drug Resistance in Cancer: Mechanisms and Strategies; Sameer Ullah Khan,Fayaz Malik Book 2024 The Editor(s) (if applicable) and The Author

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Mechanisms of Cancer Resistance to Various Therapies,urvival. This chapter provides an overview of current cancer therapies, encompassing radiation therapy, chemotherapy, targeted therapy, immunotherapy, and emerging therapeutic modalities such as viral and gene therapy. This chapter explores the intricate molecular mechanisms underpinning resistance

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Immune Cells: Critical Players in Drug Resistance,onment (TME), encompassing B cells, effector and regulatory T cells, tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), and tumor-associated neutrophils (TANs), plays a decisive role in tumorigenesis. Various studies showed that MDSCs can create immunosuppressive microenv

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Tumor Microenvironment: Multiway Role in Drug Resistance,rious cellular and noncellular components that cross talk with each other and with the tumor cells, thus supporting tumor progression. The intricate interplay between tumor cells and their surrounding microenvironment has emerged as a pivotal factor influencing the development of drug resistance in

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Epigenetic Alterations as an Adaptive Response to Chemotherapy,esponse to chemotherapy. A heritable alteration in gene expression that is unrelated to variations in the sequence of nucleotides is known as epigenetic regulation. Histone modification, noncoding RNA regulation, and DNA methylation have all been thoroughly investigated as common epigenetic regulato

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Intracellular Compartments and Drug Resistance, synthesis, energy production, and waste disposal. The intricate organization of these compartments creates distinct microenvironments that impact cellular responses to external stimuli, including drug exposure. Understanding the interplay between intracellular compartments and drug resistance is cr

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