Titlebook: Drug Resistance; William N. Hait Book 1996 Kluwer Academic Publishers 1996 DNA.Drogen.apoptosis.breast cancer.cancer.chemotherapy.drug.dru

outer-ear

https://doi.org/10.1057/9781137485335 Following the characterization and synthesis of folic acid in 1946, a number of analogues were synthesized and tested [3]. The first derivative was x-methyl-folic acid, which produced changes in blood counts, particularly granulocytes, and bone marrow in rats [4]. However, this antagonist had no activity in humans.

動機

Victorian Writers and the Stagecancer would be diagnosed in the United States and prostate cancer would account for approximately 40,400 deaths in that year [1]. The magnitude of the prostate cancer problem has focused attention on the need for better therapies and effective prevention.

Antecedent

Mast-Cell

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“Cosmonaut 13”: Vladimir Shatalov-DNA adducts, including O.-methylguanine (O.-mG). In cells with persistent O.-mG adducts, over 6,000 lesions are required to induce cell death [1]. In contrast, chloroethylating agents lead to the formation of DNA-interstrand crosslinks, only a few of which are required for cytotoxicity [2].

樹木心

Mechanisms of Resistance to Alkylating Agentsentally useful mutations. Moreover, since the therapeutic indices of most alkylating agents are low, sublethal drug exposure is frequently encountered, and this produces an ideal selection environment.

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得意牛

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脊椎動物