Titlebook: Drug Discovery in Pancreatic Cancer; Models and Technique Haiyong Han,Paul Grippo Book 2010 Springer-Verlag New York 2010 Han.cancer.diagno

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Book 2010ors. The identification and characterization of these cancer-related genes have significantly increased our understanding of pancreatic cancer development, but unfortunately the treatment of pancreatic cancer has not advanced as much in the past 20 years...Over the past decade, tremendous advances h

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Fluorescent Metastatic Mouse Models of Pancreatic Cancer for Drug Discovery, imaging equipment. We have shown a high correlation between florescent optical imaging and magnetic resonance imaging in these models. Transplantation of RFP-expressing tumor fragments onto the pancreas of GFP-expressing transgenic mice may be used to facilitate visualization of tumor–host interact

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Using Array Comparative Genomic Hybridization of Pancreatic Cancer Samples to Map Interesting Regiorall genomic profile of the pancreatic cancer genome. Mapping of regions altered in the cancer genome has helped in the identification of cancer genes, and the analysis of array CGH data from pancreatic cancer samples may yield new targets for therapeutic development.

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Proteomic Analysis of Blood and Pancreatic Juice,h as plasma/serum. The application of proteomic techniques affords opportunities for discovering and evaluating biomarkers that aid the process of drug development. In this chapter, some of the recent advances in proteomic techniques that enable the detection and quantification of proteins in blood

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Applications of Antibody-Lectin Sandwich Arrays (ALSA) to Pancreatic Cancer Diagnostics and Drug Dis, or characterize protein carriers of specific glycans. These types of experiments will be especially useful in pancreatic cancer research in studies to develop biomarkers and to define therapeutic targets.