Titlebook: Drug Discovery and Evaluation: Methods in Clinical Pharmacology; Franz J. Hock,Michael R. Gralinski Living reference work 20200th edition

細(xì)節(jié)

Dose Linearity and Proportionality,kinetics” implies that any concentration–time profiles normalized for dose and time are superimposable (Ludden 1991). Thus, one of the necessary conditions for linear pharmacokinetics is dose proportionality, and its assessment is a fundamental pharmacokinetic analysis conducted during the clinical

Presbycusis

,Drug–Drug Interaction Studies, DDIs during clinical development is a part of the general clinical pharmacology and safety assessment of a new investigational compound. Market withdrawals of drugs were frequently caused by DDIs which underlines the importance of addressing these issues during drug development. This is also reflec

衣服

Effects of Food Intake,hange the effects of drugs, and the therapeutic effects or side effects of medications can affect the nutritional status. Alternatively, the diet and the use of supplements or the nutritional status of the patient can decrease a drug’s efficacy or increase its toxicity.

取回

Experimental Methods for Evaluating Pharmacodynamic Effects of Drugs for the Pulmonary System,atients worldwide. While asthma and COPD do share a number of common features as they are chronic inflammatory conditions of the lung, they are clearly different diseases with unique characteristics and causes. However, treatment of both these diseases remains primarily the same. There is clearly a

戲服

Aggrandize

Future of Regulatory Safety Assessments,cal need for many pathological processes continues. Concerns appear that in spite of extensive workload, success of pharmaceutical activity, and included facilitated access to novel drugs, may slow down. The preclinical testing via in vitro and animal experimentation reveals limitations to select th

我們的面粉

Gender Differences in Drug Therapy,a personalized model that focusses on the characteristics of each individual patient and tailors treatment accordingly. In order to achieve the maximum benefit and minimum risk, personalized medicine needs to address multiple individual parameters including pathology, physiology, genetics, comorbidi

極少

昏迷狀態(tài)

In silico Drug Repositioning Using Omics Data: The Potential and Pitfalls, approach to treatment. Patients with different underlying biologies originating at the genomic, epigenetic, or transcriptomics levels may present with similar phenotypes at diagnosis. The same treatment may thus result in different outcomes. Using the wealth of public information that is available,

Agronomy